GRANT.
Project information.
Marta Otero Viñas leader a recently obtained grant from the Spanish Ministry of Science, Innovation, and Universities through the Instituto de Salud Carlos III-FEDER program (Acción Estratégia en Salud 2017-2020 – Proyectos de investigación en salud).
Team members: Elisabet Sarri, Marta Ferrer, Joan Espaulella, Marta Cullell, Montserrat Masoliver, Jacint Altimiras, Víctor González, Marta Casals, Montserrat Serra, and Verónica Salgado.
Original Title (spanish): “Estudio observacional: relación entre la composición y la funcionalidad in vitro del plasma rico en plaquetas autólogo y la evolución de heridas crónicas tratadas con esta terapia”.
Objectives: Complex chronic wounds in the elderly population with associated comorbidities are increasing. There is evidence that autologous platelet rich plasma therapy (PRP) reduces the healing time of chronic wounds, especially in diabetics. PRP contains factors that activate key healing processes: angiogenesis, fibroblast migration and keratinocyte proliferation. However, there are few studies that relate the composition and biological functionality of the PRP, with the clinical result of the therapy. The aim of this study is to determine the effectiveness of the PRP therapy, according to its composition. For this purpose we will test the correlation between the composition and biofunctionality of the PRP, the physical characteristics of the wounds, and clinical data of the patients with the healing steps of the wounds treated in a clinical unit of wounds (UCH).
Methodology: Prospective observational study in patients initiating PRP therapy in the UCH. Determination of the PRP composition by proteomics. Functional PRP test on cellular models of angiogenesis, migration and proliferation. Monitoring of the evolution of morphometry and tissue aspect of the wound, as well as the clinical and sociodemographic variables of the patients.
Principal Investigador: Marta Otero Viñas
Funded by: Ministerio de Ciencia, Innovación, y Universidades – Instituto de Salud Carlos III – Programa FEDER (FIS PI19/01379)
Period: 2020-22
[…] for which it has recently received research fundings from Spanish and European institutions (FIS and FEDER)*. This collaboration will help TR2Lab to continue developing and deepening research […]
[…] have been developed for supporting the implementation of two funded projects of the TR2Lab: “Observational study: correlation between the composition and the in vitro functionality of the autol…” (FIS PI19/01379) and “PECT: Osona social transformation” […]
[…] TR2Lab obtains a predoctoral grant from University of Vic – Central University of Catalonia for developing the doctoral project of the doctoral student Verónica Salgado in the context of the project “Observational study: correlation between the composition and the in vitro functionality of the autol…” […]
[…] under the supervision of Ph.D. Marta Otero Viñas on the context of the funded project: “Observational study: correlation between the composition and the in vitro functionality of the autol…” (FIS […]
[…] under the supervision of Ph.D. Marta Otero Viñas on the context of the funded project: “Observational study: correlation between the composition and the in vitro functionality of the autol…” (FIS […]
[…] of Ph.D. Marta Otero Viñas and Eliandre de Oliveira on the context of the funded project: “Observational study: correlation between the composition and the in vitro functionality of the autol…” (FIS […]
[…] her thesis degree project participating in a funded research project focus on the study of the mechanisms of action of the therapy with platelet-rich plasma (PRP) for the treatment of chronic wou… of the research line in mechanisms of tissue repair and regeneration at […]
[…] degree thesis is the first stage of the biggest project led by Ph.D. Marta Otero titled: “Observational study: correlation between the composition and the in vitro functionality of the autol…” that is focused on better understanding the mechanisms of action of this therapy for […]