GRANT.

Project information.

Marta Otero Viñas leader a recently obtained grant from the Spanish Ministry of Science, Innovation, and Universities through the Instituto de Salud Carlos III-FEDER program (Acción Estratégia en Salud 2017-2020 – Proyectos de investigación en salud).

Team members: Elisabet Sarri, Marta Ferrer, Joan Espaulella, Marta Cullell, Montserrat Masoliver, Jacint Altimiras, Víctor González, Marta Casals, Montserrat Serra, and Verónica Salgado.

Original Title (spanish): “Estudio observacional: relación entre la composición y la funcionalidad in vitro del plasma rico en plaquetas autólogo y la evolución de heridas crónicas tratadas con esta terapia”.

Objectives: Complex chronic wounds in the elderly population with associated comorbidities are increasing. There is evidence that autologous platelet rich plasma therapy (PRP) reduces the healing time of chronic wounds, especially in diabetics. PRP contains factors that activate key healing processes: angiogenesis, fibroblast migration and keratinocyte proliferation. However, there are few studies that relate the composition and biological functionality of the PRP, with the clinical result of the therapy. The aim of this study is to determine the  effectiveness of the PRP therapy, according to its composition. For this purpose we will test the correlation between the composition and biofunctionality of the PRP, the physical characteristics of the wounds, and clinical data of the patients with the healing steps of the wounds treated in a clinical unit of wounds (UCH).

Methodology: Prospective observational study in patients initiating PRP therapy in the UCH. Determination of the PRP composition by proteomics. Functional PRP test on cellular models of angiogenesis, migration and proliferation. Monitoring of the evolution of morphometry and tissue aspect of the wound, as well as the clinical and sociodemographic variables of the patients.

Principal Investigador: Marta Otero Viñas

Funded by: Ministerio de Ciencia, Innovación, y Universidades – Instituto de Salud Carlos III – Programa FEDER (FIS PI19/01379)

Period: 2020-22