Established in 2021, the research line in Neuronal Plasticity in Health and Disease focuses on the multidisciplinary study of repair and regeneration mechanisms within the central nervous system. The team is led by Ph.D. Lluís Pujadas Puigdomènech as coordinator and Senior Researcher, alongside Senior Researcher Ph.D. Esther Dalfó Capella. This research initiative is integrated into the ‘Mechanisms of Injury, Transformation, and Tissue Regeneration’ area of the TR2Lab.”
We will be focused on the understanding of molecular and cellular mechanisms regulating neuronal plasticity under physiological and pathological conditions. One of the main interests will be the study of developmental-like mechanisms that remain active in the adult brain with protective roles against neuronal pathologies. The progression of neurodegenerative diseases will be investigated focusing on the events occurring in the extracellular matrix, as well as in the process of proteinopathy as a wide-range mechanism of degeneration such as Alzhiemer’s disease and Parkinson’s Disease.
The group utilizes a specialized platform to thoroughly investigate the preclinical stages of neurodegeneration using the C. elegans model, which enables the development of therapies to be assayed prior to the onset of neurodegeneration. Our research aims not only to advance the understanding of the mechanisms underlying neurodegeneration but also to develop therapeutic strategies that enhance the quality of life for patients, their families, and caregivers.
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Our last happenings
Role of human reelin in the mechanisms of beta-amyloid propagation
GRANT Original Title (idioma): Proyectos de Generación de Conocimiento 2022 Principal Investigador: Dr. Lluís Pujadas, TR2Lab research team member Funded by: Ministerio de Ciencia e Innovación Period: 2022-2026 The project Role of human reelin in the mechanisms of beta-amyloid propagation, coordinated by the IRIS-CC and led by [...]
Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2)
Article: Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2) Authors: Antoni Parcerisas (co-primer autor) i Lluís Pujadas (co-autor de correspondència) Link: Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2) | Cerebral Cortex | Oxford Academic (oup.com) [...]
Role of extracellular matrix protein Reelin in neuronal plasticity and in Alzheimer’s Disease
Principal Investigator: Eduardo Soriano Co-Principal investigator: Lluís Pujadas Funded by:“Generation of Knowledge and Challenges of the Society” Call. Ref. PID2019-106764RB-C21 Period: 01/06/2020-31/05/2023 Budget: 381.500€ Role of extracellular matrix protein Reelin in neuronal plasticity and in Alzheimer's Disease This project has been funded with the “Generation of Knowledge and Challenges of the Society” Call. This is a competitive funding initiative that is part of Spain's State Plan for Scientific and Technical Research and Innovation, which is promoted by [...]
