LCRF Award on Advancing Breakthroughs in ALK-Positive Lung Cancer
Convoca: Lung Cancer Research Foundation
Termini: 15/07/2026

Project topics include, but are not limited to:

• Early Progression and Metastatic Patterns
  – Understanding why some ALK-positive lung cancers progress more rapidly
  – Investigating the role of leptomeningeal disease
  – Mechanisms of tumor persistence, including persister cells
• Impact of Co-Mutations and ALK Variants
  – Effects of additional mutations (e.g., MET) on tumor biology and treatment resistance
  – Differential treatment responses across ALK variants
• Tumor Microenvironment
  – Approaches to reprogram or modulate the tumor microenvironment to enhance immune activity
• Metabolic Vulnerabilities
  – Identifying metabolic pathways essential for ALK-positive tumor survival
  – Strategies to improve immunotherapy efficacy or stimulate immune recognition of ALK-positive tumors
• Novel Therapies Beyond TKIs
  – Development of vaccines, cell therapies, and other innovative therapeuticapproaches