The research in Epigenetics and tissue transformation at the TR2Lab, directed by Ph.D. Laia Bosch-Presegué is focused on studying epigenetic events in different pathologies and how different interventions can prevent their appearance, improve symptoms or contribute to
their healing.
We are focused on how an epigenetic nutrition intervention can contribute to the improvement of patients with cancer, mental illnesses, obesity, etc. And at a more molecular level, and in deep collaboration with other lines of the research group, our main interest is to elucidate the epigenetic mechanisms involved in tissue repair regeneration and contribute to the design of novel therapies.
Team
Research line coordinator: Ph.D. Laia Bosch-Presegué
Research Scientists:
Research technicians:
Doctoral Candidates:
- Montserrat Sampol
- Irene Romero
Our last happenings
A key amino acid site associated with rhodopsin mammal evolution to diurnal vision.
Authors: Fernández-Sampedro MA, Ramon E, Aguileta G, Bosch-Presegué L, Garriga P. Sci Rep. 2025 Dec 26;16(1):411 doi:10.1038/s41598-025-29872-9. Read More Abstract Rhodopsin is a photoreceptor protein found in the vertebrate retina used as a landmark for vision evolution studies at the molecular level. Here, we examined the biochemical and [...]
The diagnostic accuracy of HE4 in the differential diagnosis of pleural effusions.
Authors: Bérgamo S, Trapé J, González-García L, González-Fernández C, Vergara C, la-Torre ND, Bosch-Presegué L, Otero-Viñas M, Catot S, Crespo-Casal M, Rives-Jimenez J, Arnau A, Costa R, Cugat JR, Gonzalez-Sánchez F, Pla-Salas X, Sant F. Clin Chim Acta. 2025 Jan 30;566:120027. doi:10.1016/j.cca.2024.120027 Read More Abstract Background: Pleural effusions are [...]
Utility of human epididymis protein 4 in the differential diagnosis of ascites
Authors: Bérgamo S, Trapé J, González-García L, González-Fernández C, Vergara C, de-la-Torre N, Trujillo G, Estivill D, Álvarez-González MA, Bosch L, Otero-Viñas M, Bergós C, Catot S, Ruiz-Hidalgo D, Ros S, Sant F Clin Biochem. 2023 Oct;120:110645. doi:10.1016/j.clinbiochem.2023.110645. Read More Abstract Background and aims: Human epididymal protein 4 [...]
A complex interplay between H2A.Z and HP1 isoforms regulates pericentric heterochromatin.
Authors: González J, Bosch-Presegué L, Marazuela-Duque A, Guitart-Solanes A, Espinosa-Alcantud M, Fernandez AF, Brown JP, Ausió J, Vazquez BN, Singh PB, Fraga MF, Vaquero A Front Cell Dev Biol. 2023 Nov 9;11:1293122. doi:0.3389/fcell.2023.1293122 Read More Abstract Pericentric heterochromatin (PCH) plays an essential role in the maintenance of genome [...]
SIRT1 regulates DNA damage signaling through the PP4 phosphatase complex
Authors: Rasti G, Becker M, Vazquez BN, Espinosa-Alcantud M, Fernández-Duran I, Gámez-García A, Ianni A, Gonzalez J, Bosch-Presegué L, Marazuela-Duque A, Guitart-Solanes A, Segura-Bayona S, Bech-Serra JJ, Scher M, Serrano L, Shankavaram U, Erdjument-Bromage H, Tempst P, Reinberg D, Olivella M, Stracker TH, de la Torre C, Vaquero A. Nucleic [...]
Biomedicine Workshops: Connecting Biomedical Sciences with Upper Secondary Students
The Biomedicine Workshops, organized by TR2Lab as part of the Educational Biomedicine Program, are a well-established scientific dissemination activity aimed at high school students. The primary goal of these workshops is to bridge the gap between high school science education and university degrees. Additionally, they provide an excellent [...]
Unlocking DCIS lesions progression to prevent women overtreatment and improving their sexual and reproductive health impact
Research team Gemma Fuster, Laia Bosch-Pressegué, Cristina Martín, Antoni Parcerisas, Neus Carbó, Patrícia-Fernàndez-Nogueira, Èric Calatayud, Mónica Marro and Clara Martínez in the UVIC-UCC and IRIS-CC. Also Researcher at Vall Hebrón Research Institute leaded by Dr. Vicente Peg, and in Hospital Germans Trias i Pujol, leaded by Dr. Aintzane [...]
Biomedicine Workshops: more than 1000 High School Students and participation from all Secondary Schools in Vic
The biomedicine workshops for high school students organized by the Tissue Repair and Regeneration Research Group (TR2lab) within the Educational Biomedicine Program of TR2lab and UDivulga program of UVic-UCC are a consolidated activity aimed at establishing a link between high school scientific education and university degrees. Additionally, the workshops [...]
High-Intensity Exercise Promotes Deleterious Cardiovascular Remodeling in a High-Cardiovascular-Risk Model: A Role for Oxidative Stress
Article: High-Intensity Exercise Promotes Deleterious Cardiovascular Remodeling in a High-Cardiovascular-Risk Model: A Role for Oxidative Stress Authors: Meza-Ramos, A.; Alcarraz, A.; Lazo-Rodriguez, M.; Sangüesa, G.; Banon-Maneus, E.; Rovira, J.; Ramirez-Bajo, M.J.; Sitges, M.; Mont, L.; Ventura-Aguiar, P. Link: https://www.mdpi.com/2076-3921/12/7/1462
Up to 190 high school students from Osona and Vallès Occidental have attended the Biomedicine Workshops offered by TR2Lab within the UVIC-UCC
One more time the research group in Tissue Repair and Regeneration (TR2Lab) of the Institute for Research and Innovation in Health Sciences of Central Catalonia (IRIS-CC) since last July, has successfully organized the Biomedicine Workshops for high school students in the Biosciences laboratories of the Faculty of Science, [...]
Stay in the Research Institute Versus the Leukemia Josep Carreras.
Principal Investigador: Laia Bosch-Presegué. Collaborator: Alejandro Vaquero (Principal investigator of the Chromatin Biology Laboratory). Where: Research Institute Versus the Leukemia Josep Carreras (Barcelona) Period: April 2022. She will be studying the functional relation between the HP1 isoforms and the histone H2AZ variant in the regulation of the Heterochromatin and the [...]
New insights into the molecular mechanism of rhodopsin retinitis pigmentosa from the biochemical and functional characterization of G90V, Y102H and I307N mutations
Article: New insights into the molecular mechanism of rhodopsin retinitis pigmentosa from the biochemical and functional characterization of G90V, Y102H and I307N mutations Authors: María Guadalupe Herrera-Hernández, Neda Razzaghi, Pol Fernandez-Gonzalez, Laia Bosch-Presegué, Guillem Vila-Julià, Juan Jesús Pérez, Pere Garriga. PDF article Abstract: Objectives: Mutations in the photoreceptor protein rhodopsin are known as [...]
VI Workshop in care for chronic wounds. Advanced treatments for complex wound
GRANT Principal Investigator: Marta Otero Research Team: Laia Bosch, Elisabet Dachs, Anna Dalmau, Ester Goutan, Núria Obradors, Montserrat Serra, Elisabet Sarri, Marta Casals, Xavier Jordana, Marta Ferrer, Montse Capellas, Clara Masó, Verónica Salgado, Mireia Bosch, Joan Fernández, Óscar Pérez Funded by: Universitat de Vic – Universitat Central de Catalunya [...]
VI Workshop in biomedical scientific techniques for high school students
GRANT Principal Investigator: Marta Otero Research Team: Laia Bosch, Montserrat Capellas, Elisabet Dachs, Cristina Martín, Elisabet Sarri Funded by: Universitat de Vic – Universitat Central de Catalunya (UVIC-UCC) Ref: 003DIVC2022 Period: 2022 The Biomedicine workshops are a TR2Lab project to promote scientific vocations among high school students. [...]
Maria Cristina Martin joins TR2Lab
Proud to incorporate Maria Cristina Martín as a new researcher of the TR2Lab. Welcome, Maria Cristina Martin, who joins the research line in Applied Epigenetics of the TR2Lab. Maria Cristina Martin is also a technician in Biosciences Laboratories in the Faculty of Science and Technology at the University of [...]
Successful third Seminar of the ACCESSIBLE SCIENCE program
On May 5th was developed the third seminar session of the ACCESSIBLE SCIENCE program: New scientific advances to bring to high school classrooms Success in the third seminar of the ACCESSIBLE SCIENCE program conducted by Ph. Elisabet Dachs focused on what the gene therapy using CRISPR offers. Support materials on [...]
“UDivulga. Ciència i Societat” project
GRANT Original Title (catalan): "UDivulga. Ciència i Societat" Principal Investigador: Pilar López TR2Lab research team members: Marta Otero Viñas, Laia Bosch, Elisabet Dachs, Anna Dalmau, Ester Goutan, Xavier Jordana, Elisabet Sarri. Funded by: Fundación Española para la Ciencia y la Tecnología (FECYT) - FCT-19-14267. Period: 2020-21 Project [...]
New allosteric ligands of the visual G protein coupled receptor rhodopsin and the molecular mechanism of retinal degenerative diseases
GRANT. Project information. Laia Bosch-Presegué participates in grant from the Ministerio de Ciencia, Innovación y Universidades. Principal Investigador: Pere Garriga TR2Lab research team members: Laia Bosch-Presegué. Funded by: Ministerio de Ciencia, Innovación y Universidades (PID2019-104817GB-I00) Period: 2020
SARS-CoV-2, el virus que de la nit al dia ens ha canviat la vida i ens ha immers en un món ple de tecnicismes
ARTICLE. Elisabet Dachs-Cabanas i Laia Bosch-Presegué. SARS-CoV-2, el virus que de la nit al dia ens ha canviat la vida i ens ha immers en un món ple de tecnicismes. UDivulga. Ciència i Societat. UVIC-UCC. June 4th, 2020 Dissemination article (original language: catalan): More information
V Workshop in care for chronic wounds. Update on the wound infection
GRANT. Project information. TR2Lab has obtained a grant for organizing the fifth workshop in wound care. Original Title (catalan): "Jornada d’Atenció a les Ferides 2020. La infecció: de la valoració al tractament tòpic i al sistèmic" Principal Investigador: Marta Otero Viñas Research Team: Laia Bosch Presegué, Elisabet Dachs Cabanas, Anna [...]
V Workshop in biomedical scientific techniques for high school students
GRANT. Project information. TR2Lab has obtained a grant for promoting scientific vocations to high school students. Original Title (catalan): "Taller científic en tècniques biomèdiques per a estudiants de batxillerat" Principal Investigator: Marta Otero Viñas Research Team: Elisabet Sarri Plans, Luís Agulló Rueda, Laia Bosch Pressegué, Elisabet Dachs Cabanas, Anna Dalmau [...]
Laia Bosch Joins TR2Lab
Proud to incorporate Laia Bosch as a new researcher of the TR2Lab. Welcome, Laia Bosch-Presegué, who joins to the research line of applied epigenetics of the TR2Lab. Laia Bosch-Presegué is an expert in epigenetics and molecular biology, a field in which she conducted her doctoral thesis and her postdoctoral research. Check [...]
TR2Lab creates a new research line in Applied Epigenetics
Proud to create a new research line focused on Applied Epigenetics. Epigenetics is a very new science that studies changes in the genome marks that do not imply a change in the DNA sequence but that can be transmitted between generations. These marks are known as epigenetic marks and have [...]
Colloquium lecture “Pessics de Ciència”
From the TR2Lab commitment to science dissemination, 0n May 28, the PhDs Elisabet Dachs Cabanas and Laia Bosch-Presegué participated in a scientific dissemination conference at the Cafè del Teatre de l’Escorxador in the City of Lleida, within the "Pessics de Ciència" program, that organizes several talks throughout of the year. [...]
Dissecting the specific contribution of Sirtuin ADP-ribosyltransferse and deacetylase activities in tumorigenesis.
GRANT. Project information. Laia Bosch-Presegué participates in grant from the Ministerio de Ciencia, Innovación y Universidades. Principal Investigador: Alejandro Vaquero TR2Lab research team members: Laia Bosch-Presegué. Funded by: World Wide Cancer Research Period: 2018
