Gemma Fuster has just published a research article in collaboration with Hospital de Sant Pau and Hospital Clínic where the researchers analyse the predictive capacity for local disease control of the transcriptional expression of the neogenin-1 (NEO1) gene in patients with head and neck squamous cell carcinoma (HNSCC). We performed a retrospective neogenin-1 (NEO1) transcriptional study on tumour biopsies from 107 surgically treated HNSCC patients. Neogenin-1 is the receptor for netrin-1 and has been classified as a tumour suppressor gene in some cancers, such as colorectal cancer. In contrast, in this study shows that HNSCC patients with lower transcriptional expression of NEO1 have a significantly higher risk of local recurrence after surgical treatment.

Keywords: Head and neck squamous cell carcinoma; Local recurrence; NEO1; Neogenin-1; Surgery.

Authors: Xavier León, Cristina Valero, Gemma Fuster, Paloma Bragado, Mercedes Camacho, Francesc-Xavier Avilés-Jurado.

Link: https://pubmed.ncbi.nlm.nih.gov/38898351/