Elisabet Selga Coma
Coordinator of the Determinants of Arrhythmogenesis Research Line
Email: elisabet.selga@umedicina.cat
ORCID: 0000-0002-4290-8370
Scientific Profile: URECERCA
Elisabet Selga is an associate professor at the Faculty of Medicine of the Universitat de Vic – Universitat Central de Catalunya.
Dr. Selga is a biologist (2004, UdG) and developed her Ph.D. on the identification of genomic nodes involved in the response to chemotherapeutic treatment with methotrexate (2009, UB). Then she moved to IDIBGI, and under a postdoctoral Sara Borrell fellowship (2012 – 2014), Dr. Selga investigated the pathophysiological effects of genetic variants in cardiac ion channels identified in patients with inherited cardiac disorders and in cases of unexplained sudden death. Her international research stay (2013 – 2014) at the prestigious MRC Centre for Regenerative Medicine in Edinburgh allowed her to implement patient-specific induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) as a cellular model to assess pathophysiological mechanisms and pharmacological responses in patients with Brugada syndrome.
In 2018 she moved to UVic-UCC as professor, and joined IRIS-CC. Since then, her research interests are I) to uncover the cardiac and neurological risk factors that lead to sudden cardiac death, and II) to quantify the impact of a holistic cardiac rehabilitation program on clinical and biochemical biomarkers, on the microbiome and on the mechanisms of atrial inflammation in patients diagnosed with atrial fibrillation and overweight/obesity.
My last happenings:
A key amino acid site associated with rhodopsin mammal evolution to diurnal vision.
Authors: Fernández-Sampedro MA, Ramon E, Aguileta G, Bosch-Presegué L, Garriga P. Sci Rep. 2025 Dec 26;16(1):411 doi:10.1038/s41598-025-29872-9. Read More Abstract Rhodopsin is a photoreceptor protein found in the vertebrate retina used as a landmark for vision evolution studies at the molecular level. Here, we examined the biochemical and functional performance of modern rhodopsin from three different mammal species- bovine, murine and human-to analyze their visual pigment evolutionary relationships. We selected these species for their relevance in vision research, their different position on the phylogenetic tree and their diverse ethology regarding nocturnal (mouse) and diurnal (bovine and human) life. [...]
The diagnostic accuracy of HE4 in the differential diagnosis of pleural effusions.
Authors: Bérgamo S, Trapé J, González-García L, González-Fernández C, Vergara C, la-Torre ND, Bosch-Presegué L, Otero-Viñas M, Catot S, Crespo-Casal M, Rives-Jimenez J, Arnau A, Costa R, Cugat JR, Gonzalez-Sánchez F, Pla-Salas X, Sant F. Clin Chim Acta. 2025 Jan 30;566:120027. doi:10.1016/j.cca.2024.120027 Read More Abstract Background: Pleural effusions are challenging to diagnose, with approximately 20-50% of malignant effusions not diagnosed by cytology. Human epididymal protein 4 (HE4) may be useful in the differential diagnosis of pleural effusions. In serum, this biomarker shows false-positive results in some benign diseases. The aim of this study was to evaluate the diagnostic utility [...]
Utility of human epididymis protein 4 in the differential diagnosis of ascites
Authors: Bérgamo S, Trapé J, González-García L, González-Fernández C, Vergara C, de-la-Torre N, Trujillo G, Estivill D, Álvarez-González MA, Bosch L, Otero-Viñas M, Bergós C, Catot S, Ruiz-Hidalgo D, Ros S, Sant F Clin Biochem. 2023 Oct;120:110645. doi:10.1016/j.clinbiochem.2023.110645. Read More Abstract Background and aims: Human epididymal protein 4 (HE4) may be a useful tool in the differential diagnosis of malignant ascites. The aim of this study was to evaluate the diagnostic utility of HE4 for detecting malignant ascites, taking into account the possible false positives identified with adenosine deaminase (ADA), C-reactive protein (CRP), % polynuclear cells (%PMN) and [...]
