Effect of photobiomodulation in an experimental in vitromodel of asthma-Copd overlap

Article: Effect of photobiomodulation in an experimental in vitromodel of asthma-Copd overlap.

Coauthors: Marina Bertoni Guerra, Kelly Gomes Santana, Marcos Momolli, Rodrigo Labat, Maria Cristina Chavantes, Stella Regina Zammuner, José Antonio Silva Júnior, Renata Kelly da Palma, Flavio Aimbire, Ana Paula Ligeiro de Oliveirae

Acces to article: 

Abstract:

The objective of the study was to evaluatethe effect of photobiomodulation (PBM)with laser on the inflammatory process inan experimental in vitro model of ACO. The groups were: (1) human bronchialepithelial cells (BEAS-2B); (2) BEAS-2B cells treated with dexamethasone;(3) BEAS-2B cells irradiated with laser; (4) BEAS-2B cells stimulated with ciga-rette smoke extract (CSE) + House Dust Mite (HDM); (5) BEAS-2B cells stim-ulated with CSE + HDM and treated with dexamethasone; (6) BEAS-2B cellsincubated with CSE + HDM and irradiated with laser. After 24 h, cytokineswere quantified. There was a reduction in TNF-α, IL-1β, IL-6, IL-4, IL-5, IL-13,IL-17, IL-21, IL-23, and an increase in IL-10 and IFN-γ in cells from the laser-irradiated ACO group compared to only ACO group. With these results, wecan suggest that photobiomodulation acts in the modulation of inflammationobserved in ACO, and may be a treatment option.

Keywords:

asthma-COPD overlap, cytokines, low level laser, photobiomodulation