Xavier Rovira 2017

Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation.

ARTICLE. Scholler P, Nevoltris D, de Bundel D, Bossi S, Moreno-Delgado D, Rovira X, Møller TC, El Moustaine D, Mathieu M, Blanc E, McLean H, Dupuis E, Mathis G, Trinquet E, Daniel H, Valjent E, Baty D, Chames P, Rondard P, Pin JP. Nat Commun. 2017 Dec 6;8(1):1967. doi: 10.1038/s41467-017-01489-1. [...]

  • Photopharmacology symposium

Xavier Rovira organized a symposium about Photophamarcology within the FEB3+ Meeting in Barcelona

MEETING. Xavier Rovira,  director of the research line in Molecular Photopharmacology at the TR2Lab, organized a symposium about Photophamarcology within the FEB3+ Meeting in Barcelona. The FEBS3+ Meeting - XL SEBBM CONGRESS 2017 is the Annual Congress of the Sociedad Española de Bioquímica y Biología Molecular (SEBBM) which this year will [...]

Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer.

ARTICLE. Liu J, Zhang Z, Moreno-Delgado D, Dalton JA, Rovira X, Trapero A, Goudet C, Llebaria A, Giraldo J, Yuan Q, Rondard P, Huang S, Liu J, Pin JP. Elife. 2017 Aug 10;6. pii: e26985. DOI: 10.7554/eLife.26985. PubMed PMID: 28829739; PubMed Central PMCID: PMC5582870. Abstract. GPCRs play critical roles in cell communication. [...]

Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells

ARTICLE. Moreno Delgado D, Møller TC, Ster J, Giraldo J, Maurel D, Rovira X, Scholler P, Zwier JM, Perroy J, Durroux T, Trinquet E, Prezeau L, Rondard P, Pin JP. Elife. 2017 Jun 29;6. pii: e25233. DOI: 10.7554/eLife.25233. PubMed PMID: 28661401; PubMed Central PMCID: PMC5540479. Abstract.  Metabotropic glutamate receptors (mGluRs) [...]

Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

ARTICLE.Font J, López-Cano M, Notartomaso S, Scarselli P, Di Pietro P, Bresolí-Obach R, Battaglia G, Malhaire F, Rovira X, Catena J, Giraldo J, Pin JP, Fernández-Dueñas V, Goudet C, Nonell S, Nicoletti F, Llebaria A, Ciruela F. elife. 2017 Apr 11;6. pii: e23545. doi: 10.7554/eLife.23545. Abstract. Light-operated drugs constitute a [...]

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