Epigenetics and tissue transformation

Dissecting the specific contribution of Sirtuin ADP-ribosyltransferse and deacetylase activities in tumorigenesis.

GRANT. Project information. Laia Bosch-Presegué participates in grant from the Ministerio de Ciencia, Innovación y Universidades. Principal Investigador: Alejandro Vaquero TR2Lab research team members: Laia Bosch-Presegué. Funded by: World Wide Cancer Research Period: 2018

Sirtuin-dependent protection of genome stability under stress and its implications in cáncer and aging.

GRANT. Project information. Laia Bosch-Presegué participates in grant from the Ministerio de Ciencia, Innovación y Universidades. Principal Investigador:Alejandro Vaquero TR2Lab research team members: Laia Bosch-Presegué. Funded by: Ministerio de Ciencia, Innovación y Universidades Period: 2018

SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway

ARTICLE. Santos-Barriopedro I, Bosch-Presegué L, Marazuela-Duque A, de la Torre C, Colomer C, Vazquez BN, Fuhrmann T, Martínez-Pastor B, Lu W, Braun T, Bober E, Jenuwein T, Serrano L, Esteller M, Chen Z, Barceló-Batllori S, Mostoslavsky R, Espinosa LL, Vaquero A. SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 [...]

Mammalian HP1 Isoforms Have Specific Roles in Heterochromatin Structure and Organization

ARTICLE. Bosch-Presegué L, Raurell-Vila H, Thackray JK, González J, Casal C, Kane-Goldsmith N, Vizoso M, Brown JP, Gómez A, Ausió J, Zimmermann T, Esteller M, Schotta G, Singh PB, Serrano L, Vaquero A. Mammalian HP1 Isoforms Have Specific Roles in Heterochromatin Structure and Organization. Cell Rep. 2017 Nov 21;21(8):2048-2057. doi: 10.1016/j.celrep.2017.10.092. [...]

An HP1 isoform-specific feedback mechanism regulates Suv39h1 activity under stress conditions

ARTICLE. Raurell-Vila H, Bosch-Presegué L, Gonzalez J, Kane-Goldsmith N, Casal C, Brown JP, Marazuela-Duque A, Singh PB, Serrano L, Vaquero A. An HP1 isoform-specific feedback mechanism regulates Suv39h1 activity under stress conditions. Epigenetics. 2017 Feb;12(2):166-175. doi: 10.1080/15592294.2016.1278096. Epub 2017 Jan 6. Abstract. The presence of H3K9me3 and heterochromatin protein 1 [...]

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